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By Frederick F. Holmes M.D. (auth.)

The lifetime of a person is finite, and all people age (see Fries 1980). it really is tough to split the consequences of affliction on organs and tissues from these anticipated of getting older. this is often rather real for vascular and degenerative methods, for which there are not any transparent barriers among getting older and sickness. Morbidity and mortality from center sickness and stroke are most likely due either to disorder and to adjustments of getting older. For melanoma, the second one best explanation for dying in the USA, the placement is kind of diversified; melanoma is obviously a affliction and isn't a transformation anticipated with getting older. melanoma occurrence raises virtually logarithmically after age forty. within the usa approximately one-half of all instances of melanoma are clinically determined after age sixty five, even though these over sixty five contain lower than one-eighth of the inhabitants. hence, melanoma is especially a lot a ailment of the aged. There are no less than purposes for this: first, the lengthy publicity to cancer-inducing brokers, and moment, the waning strength of immune defenses opposed to cancer.

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2. Years survival by age and time groups for locally confined ovarian cancer 10 0 3 85-74 3 75-84 5 3 85-94 32 Ovary The other challenge is improvement in the control of disease not cured. There is reason to believe that radiotherapy and chemotherapy regimens can be improved for patients with residual disease after surgery or recurrent disease later. The good results in widespread disease raise expectations here. Distant Just about half of the cases of ovarian cancer have reached this stage by the time of diagnosis.

Years survival by age and time groups for distantly spread bladder cancer However, there is less propensity toward chronicity, and there are few deaths with or of the disease after 5 years. Thus, cure is likely with survival to 5 years, and the absolute cure rate is actually in the neighborhood of 30%. In contrast to the local stage of this disease and to many other regional cancers, there is no mitigation of mortality with advancing age. Virtually all patients in the 85-94 age-group died with or of bladder cancer.

40 30 20 '0 0 I 3 65-74 I 5 I 3 75-84 3 85-94 Fig. 3. J ~ :;: so a: :I II) 40 30 20 10 0 3 65-74 I 3 75-84 3 85-94 Fig. 4. Years survival by age and time groups for distantly spread cervical cancer Distant 41 Distant There is not a sufficient number of cases for plotting survival curves for any of the three age groups (Fig. 4). Perhaps this is a good omen, because distantly spread cervical cancer is essentially an untreatable disease. For all intents and purposes chemotherapy is without effect.

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